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Updated: Aug 15, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.7K

[Role of non-coding RNAs in vascular smooth muscle cell calcification]

Hang Yu1, Da-Ling Zhu1,2

  • 1Branch Campus of Daqing, Harbin Medical University, Daqing 163311, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|January 3, 2023
PubMed

Insights

Vascular calcification, a key factor in cardiovascular disease, involves non-coding RNAs. This review explores how these molecules regulate vascular smooth muscle cell calcification and related pathways.

Area of Science:

  • Biomedical science
  • Molecular biology
  • Cardiovascular research

Context:

  • Vascular calcification contributes significantly to cardiovascular and cerebrovascular disease morbidity and mortality.
  • It is a critical biomarker for conditions like atherosclerosis, stroke, and peripheral vascular diseases.
  • The precise mechanisms underlying vascular calcification remain incompletely understood.

Purpose:

  • To review the primary types of non-coding RNAs implicated in vascular calcification.
  • To elucidate the roles of non-coding RNAs in vascular smooth muscle cell calcification.
  • To examine the influence of non-coding RNAs on osteoblast-related proteins, calcification signaling pathways, and intracellular calcium (Ca2+).

Summary:

  • Non-coding RNAs (ncRNAs) are increasingly recognized for their crucial roles in the pathogenesis of vascular calcification.
  • This review details how specific ncRNAs modulate key cellular processes, including the expression of osteoblast-related proteins.
  • The impact of ncRNAs on intracellular Ca2+ homeostasis and signaling cascades central to vascular calcification is discussed.

Impact:

  • Provides a comprehensive overview of ncRNAs in vascular calcification, aiding researchers in understanding disease mechanisms.
  • Highlights potential therapeutic targets for managing vascular calcification and associated cardiovascular diseases.
  • Enhances knowledge of molecular regulators involved in arterial wall stiffening and cardiovascular events.

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