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Association Between Traumatic Brain Injury and Increased Risk of Stroke: A Systematic Review and Meta-analysis.

Dmitry Esterov1, Michael A Sperl, Emily A Hines

  • 1Department of Physical Medicine and Rehabilitation (Drs Esterov and Brown) and Mayo Medical Library (Ms Kinzelman Vesely), Mayo Clinic, Rochester, Minnesota; and Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota (Drs Sperl and Hines).

The Journal of Head Trauma Rehabilitation
|January 3, 2023
PubMed
Summary
This summary is machine-generated.

Traumatic brain injury (TBI) significantly increases stroke risk in adults. This risk applies across all injury severities and phases, highlighting the need for improved stroke prevention strategies post-TBI.

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Area of Science:

  • Neuroscience
  • Public Health
  • Epidemiology

Background:

  • Traumatic brain injury (TBI) is a significant public health concern.
  • The association between TBI and subsequent stroke risk requires further elucidation.
  • Understanding this association across injury severity and time is crucial for patient management.

Approach:

  • Systematic review and meta-analysis of observational studies.
  • Searches conducted across major scientific databases (MEDLINE, Embase, Scopus, Web of Science).
  • Included 8 cohort studies with over 600,000 participants, assessing TBI as exposure and stroke as outcome.

Key Points:

  • TBI is associated with a 2-fold increased risk of stroke (HR, 2.06; 95% CI, 1.28-3.32).
  • The association between TBI and stroke risk was consistent across injury severities.
  • A smaller risk of ischemic stroke was observed compared to all stroke types.

Conclusions:

  • TBI, irrespective of severity, elevates the risk of stroke.
  • Further research is needed to precisely classify TBI severity and stroke types for better risk prediction.
  • Enhanced secondary stroke prevention strategies are warranted for TBI survivors.