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Computational modeling of endovascular peripheral nerve stimulation using a stent-mounted electrode array.

Jing Yang Liu1, David B Grayden1, Janet R Keast1

  • 1Department of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria 3053, Australia.

Journal of Neural Engineering
|January 3, 2023
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Summary

Endovascular stent-electrode arrays show feasibility for peripheral nerve stimulation. Computational models indicate optimized configurations can achieve low stimulation thresholds for treating neurological disorders.

Keywords:
endovascular peripheral nerve stimulationfinite element modelpudendal nervestentrodevagus nerve

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Area of Science:

  • Biomedical Engineering
  • Computational Neuroscience
  • Medical Devices

Background:

  • Endovascular neuromodulation offers a minimally invasive strategy for neurological disorder treatment.
  • Peripheral nerve stimulation is crucial for various therapeutic applications.

Purpose of the Study:

  • To computationally model and assess the feasibility of endovascular stent-mounted electrode arrays for peripheral nerve stimulation.
  • To investigate the impact of electrode configuration on stimulation thresholds and axon recruitment.

Main Methods:

  • Development of anatomically realistic finite element method (FEM) models for pudendal and vagal neurovascular bundles.
  • Simulation of electromagnetic fields and axonal responses using Sim4Life NEURON models.

Main Results:

  • Stimulation thresholds for stent-electrode arrays are comparable to ring electrodes.
  • Thresholds depend on inter-electrode distance and device orientation.
  • Longitudinal electrode arrangement reduces surface charge density without compromising axon recruitment.
  • Circumferential arrangement minimizes misalignment risk but reduces axon recruitment.

Conclusions:

  • Endovascular stent-electrode arrays are predicted to be a feasible option for peripheral nerve stimulation.
  • Flexible optimization of electrode array design can achieve minimal stimulation thresholds.