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Chronic dihydroergotoxine administration increases muscarinic cholinergic receptor binding in aged-rat brain
1Institute for Neurobiology, Okayama University Medical School, Japan.
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1987
Abstract:
Changes in the distribution and densities of muscarinic cholinergic receptors (mCh-R) and the effects of dihydroergotoxine (DHET) administration on these changes were studied in the aged-rat brain by in vitro autoradiography. mCh-R binding in the brain was markedly reduced in aged rats as compared with young adult rats, but chronic administration of DHET specifically recovered mCh-R binding in the temporal cortex and hippocampus.