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Updated: Aug 15, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
A one-pot protocol for iron-catalyzed decarbonylative borylation of aryl and alkyl carboxylic acids
Mei Bai1, Shasha Geng2, Shuo Chen2
1Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563003, China.
Abstract:
We present a protocol for the eco-friendly synthesis of aryl and alkyl boronic esters from aryl and alkyl carboxylic acids. We describe steps for aryl and alkyl carboxylates preparation. We further detail procedures for the synthesis of borylated products using aryl and alkyl carboxylates through iron-catalyzed decarbonylation at 100°C-130°C, followed by purification of the crude products by flash column chromatography. For complete details on the use and execution of this protocol, please refer to Wen et al. (2022).1.
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