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A typical multisite invasive infection caused by hvKP: A case report and literature review
Jia Liu1, Mingying Dai2, Qiang Sun2
1College of Medicine, Qingdao University, Qingdao, China.
Rationale:
Hypervirulent K. pneumoniae (hvKP) is a new variant of K. pneumoniae that can caused metastatic spreading by blood, including Splenic abscess, endogenous endophthalmitis, purulent meningitis. This report described a case of A typical multisite invasive infection caused by hvKP and carry out a historical review of the literature.
Patient Concerns:
A 55-year-old man was referred to our hospital due to liver abscess. Diabetes was found during this hospitalization. Because of glycemic was uncontrolled, splenic abscess, endogenous endophthalmitis and purulent meningitis occurred during subsequent treatment.
Diagnoses:
We made s diagnosis of liver abscess and invasive K. pneumoniae liver abscess syndrome through generation sequencing and imaging features.
Interventions And Outcomes:
The patient recovered and was subsequently discharged after mechanical ventilation, continuous renal replacement therapy, laparoscopic exploration and various antimicrobials.
Lessons:
HvKP are very aggressive and can disseminate to multiple sites, especially in patient who have diabetes, which is a treatment challenge for clinician.
Insights
Hypervirulent Klebsiella pneumoniae (hvKP) can cause aggressive, invasive infections spreading to multiple organs. Uncontrolled diabetes significantly increases the risk and challenges treatment for clinicians.
Area of Science:
- Infectious Diseases
- Microbiology
- Genomics
Background:
- Hypervirulent Klebsiella pneumoniae (hvKP) is an emerging pathogen causing severe, metastatic infections.
- hvKP infections can manifest as splenic abscess, endophthalmitis, and meningitis.
- This report details a case of a typical multisite invasive infection by hvKP.
Approach:
- A 55-year-old male patient with a liver abscess was diagnosed with uncontrolled diabetes.
- Subsequent development of splenic abscess, endophthalmitis, and meningitis occurred during hospitalization.
- Diagnosis was confirmed via whole-genome sequencing and advanced imaging.
Key Points:
- The patient experienced a severe, multisite invasive infection attributed to hvKP.
- Management involved mechanical ventilation, renal replacement therapy, and surgical exploration.
- The patient ultimately recovered and was discharged.
Conclusions:
- hvKP demonstrates high virulence and a propensity for widespread dissemination.
- Patients with uncontrolled diabetes are particularly susceptible to severe hvKP infections.
- These infections pose significant clinical challenges requiring aggressive management.
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