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Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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Related Experiment Video

Updated: Aug 15, 2025

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

Association between polymorphisms in miRNAs and ischemic stroke: A meta-analysis.

Yunnan Jing^1,2, Siya Hu^1,3, Jing Song²

¹Heilongjiang University of Chinese Medicine, Harbin, China.

|January 3, 2023

Summary

Four microRNA (miRNA) polymorphisms were analyzed for their association with ischemic stroke (IS) risk. While some showed no link, others, like miR-149 and miR-499, were associated with increased IS risk.

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Last Updated: Aug 15, 2025

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

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Published on: July 3, 2018

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

Area of Science:

Genetics
Cardiovascular Research
Neurology

Background:

Atherosclerosis is a primary driver of ischemic stroke (IS).
MicroRNA (miRNA) polymorphisms are implicated in atherosclerosis.
Investigating miRNA polymorphisms may reveal predictive markers for IS.

Conclusions:

All four single nucleotide polymorphisms (SNPs) showed associations with the risk of IS or SAO.
The findings suggest that certain miRNA polymorphisms may contribute to the risk of cerebrovascular diseases like IS and SAO.
Despite inconsistencies in overall and subgroup analyses, these miRNA SNPs warrant further investigation in relation to atherosclerosis and stroke.