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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional

Hiromasa Kitamura1, Shigeru Tanaka1, Hiroto Hiyamuta2

  • 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences.

Journal of Atherosclerosis and Thrombosis
|January 3, 2023
PubMed

Insights

Cardiovascular risk factors like hypertension and diabetes worsen with chronic kidney disease (CKD) progression. Management targets become harder to reach in advanced CKD stages, especially for hypertension in very high-risk patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a major complication in chronic kidney disease (CKD).
  • Effective management of cardiovascular risk factors is crucial for CKD patients.
  • Limited data exist on the prevalence and treatment of CVD risk factors across CKD stages in clinical practice.

Purpose of the Study:

  • To investigate the burden and treatment status of cardiovascular risk factors in non-dialysis-dependent CKD patients.
  • To analyze how these factors and their management vary across different CKD severity stages.

Main Methods:

  • Cross-sectional analysis of 3,407 non-dialysis-dependent CKD patients from the Fukuoka Kidney disease Registry Study.
  • Patients stratified into five risk groups based on KDIGO 2012 guidelines (eGFR and albuminuria).
  • Logistic regression used to assess the association between CKD risk groups and cardiovascular risk factor treatment.

Main Results:

  • Hypertension, diabetes mellitus, and dyslipidemia prevalence increased with CKD severity.
  • Achievement rates for cardiovascular risk factor treatment targets decreased as CKD progressed.
  • Extremely high-risk CKD patients had significantly higher odds of uncontrolled hypertension (OR 3.68) compared to low-risk patients.

Conclusions:

  • CKD patients exhibit a growing burden of cardiovascular risk factors as kidney disease severity increases.
  • Managing hypertension poses a significant challenge in extremely high-risk CKD patients.
Abstract

Keywords:
Cardiovascular diseaseChronic kidney diseaseEstimated glomerular filtration rateTreatment controlUrinary albumin to creatinine ratio

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