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Recurrence is Not Associated with Margin Status in Phyllodes Tumor.
Kyung-Hwak Yoon1, Eunyoung Kang1, Eun-Kyu Kim1
1Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Annals of Surgical Oncology
|January 3, 2023
Summary
Surgical margins do not significantly impact Phyllodes tumor recurrence. Local excision may suffice for benign and borderline cases, even with positive margins, suggesting watchful waiting as a viable option.
Area of Science:
- Oncology
- Surgical Pathology
- Breast Surgery
Background:
- Phyllodes tumors (PT) are rare fibroepithelial breast neoplasms.
- Optimal surgical resection margins for PT remain debated.
- This study addresses PT recurrence and local recurrence (LR) risk factors.
Purpose of the Study:
- Investigate optimal surgical margins to prevent PT recurrence.
- Evaluate risk factors associated with local recurrence (LR) after PT surgery.
Main Methods:
- Retrospective analysis of a prospective cohort database.
- Included patients underwent curative surgery for PT.
- Data collected from Seoul National University Bundang Hospital (2003-2022).
Main Results:
- No significant difference in 5-year disease-free survival (DFS) based on margin status.
- Tumor size >5 cm and infiltrative border are independent risk factors for LR.
- Histologic grade did not affect DFS in relation to margin involvement.
Conclusions:
- Margin status does not significantly influence PT recurrence across histologic grades.
- Local excision without wide margins may be sufficient for benign and borderline PT.
- Watchful waiting is a potential option for patients with positive margins post-surgery.
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