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Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis

Amir Sadra Zangouei1,2, Malihe Zangoue3,4, Negin Taghehchian5

  • 1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Biological Research
|January 3, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial for regulating the cell cycle in breast cancer (BCa). These molecules show promise as non-invasive biomarkers for early BCa detection by targeting cell cycle progression.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biomarker Discovery

Background:

  • Cell cycle regulation is a critical factor in tumor progression, with most molecular pathways in cancer cells influencing this process.
  • Early diagnosis of breast cancer (BCa) is essential for effective management and treatment, necessitating the identification of non-invasive diagnostic markers.
  • Long non-coding RNAs (lncRNAs) exhibit superior stability in body fluids compared to messenger RNAs (mRNAs), making them suitable candidates for non-invasive detection.

Purpose of the Study:

  • To review and summarize all reported lncRNAs involved in cell cycle regulation specifically within breast cancer.
  • To highlight the potential of cell cycle-related lncRNAs as novel, non-invasive biomarkers for the early detection of BCa.

Main Methods:

  • Comprehensive literature review of studies reporting lncRNAs associated with cell cycle regulation in breast cancer.
  • Analysis of the mechanisms by which lncRNAs influence cell cycle progression in BCa cells.

Main Results:

  • lncRNAs play a significant role in regulating the cell cycle in breast cancer.
  • The primary mechanism involves lncRNAs affecting the G1/S transition, often through interaction with the Cyclin D1/CDK4-6 complex.
  • lncRNAs are identified as key regulators in the cell cycle machinery of BCa.

Conclusions:

  • Cell cycle-related lncRNAs are implicated in breast cancer development and progression.
  • The findings support the potential of using these lncRNAs as sensitive and specific non-invasive biomarkers for early BCa diagnosis.
  • This review provides a foundation for developing novel diagnostic strategies based on lncRNA profiles.
Keywords:
Breast cancerCell cycleDiagnosisLiquid biopsyLncRNAs

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