Related Experiment Video

Updated: Aug 15, 2025

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

18.6K

Towards hepatitis C elimination in France: Scanvir, an effective model to test and treat drug users on dedicated days

Marilyne Debette-Gratien1, Sandrine François1, Catherine Chevalier2

  • 1Hepato-Gastroenterology Department, University Hospital Center, Limoges, France.

Journal of Viral Hepatitis
|January 3, 2023
PubMed

Insights

The Scanvir program efficiently screens for hepatitis C virus (HCV) using innovative point-of-care testing and multidisciplinary teams. This strategy successfully initiated treatment for most patients, advancing HCV elimination goals.

Area of Science:

  • Hepatology
  • Public Health
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) elimination by 2025 is a French public health goal.
  • Screening policies and treatment access are being expanded.
  • The Scanvir program targets hard-to-reach populations in addiction centers.

Purpose of the Study:

  • To evaluate the efficacy of the Scanvir program for HCV screening and treatment initiation.
  • To assess the feasibility of integrated screening and care in addiction settings.
  • To determine the prevalence of HCV infection and advanced fibrosis within the target population.

Main Methods:

  • Implementation of dedicated screening days ('Scanvir') in addiction care centers.
  • On-site utilization of rapid diagnostic tests (RDTs), FibroScan®, and point-of-care HCV RNA testing.
  • Provision of access to a multidisciplinary team for immediate consultation and treatment initiation.

Main Results:

  • 392 patients attended 67 Scanvir sessions.
  • 31.6% tested HCV antibody-positive, with 66% of those being HCV RNA-positive (viremic).
  • Treatment was initiated on-site for 80% of viremic patients, with high acceptance of RDTs and FibroScan®.

Conclusions:

  • Scanvir is an efficient, cost-effective strategy for HCV elimination, integrating screening and care.
  • The program successfully engages patients and facilitates rapid treatment initiation.
  • Scanvir is an exportable model that also screens for chronic liver diseases.
Keywords:
HCV eliminationHCV screeningdrug usersliver elastometrypoint-of-care HCV RNA assay

More Related Videos

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus06:28

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

13.5K
A Protocol for Analyzing Hepatitis C Virus Replication13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.2K

Related Concept Videos

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
70
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.4K
Drug Elimination: Non-Renal Routes01:23

Drug Elimination: Non-Renal Routes

The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
2.4K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
182
Drug Elimination: Overview01:18

Drug Elimination: Overview

Drug elimination involves many complex processes and does not necessarily differentiate between distribution and elimination. It is divided into two primary components: excretion and biotransformation.
Excretion refers to removing a drug from the body, either in its unchanged form or as its metabolites. Nonvolatile and polar drugs are primarily excreted through the kidneys, with other pathways including bile, sweat, saliva, and milk. Volatile drugs such as anesthetic gases are excreted via the...
1.8K
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
93