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Updated: Aug 15, 2025
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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
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Sphingosine-1-phosphate related signalling pathways manipulating virus replication.
Lu Zhang1, Juan Liu1, Erya Xiao1
1Center of Clinical Laboratory, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China.
Reviews in Medical Virology
|January 4, 2023
Summary
The sphingosine kinase/sphingosine-1-phosphate (SphK/S1P) axis influences viral replication. This review explores its roles in various viral infections and discusses S1P-based therapeutic strategies.
Area of Science:
- Virology
- Cell Biology
- Biochemistry
Background:
- Viruses manipulate cellular environments to aid replication and transmission.
- Sphingosine kinases (SphKs) produce sphingosine-1-phosphate (S1P), a key signaling lipid.
- S1P activates G-protein coupled receptors (S1PR1-5), impacting physiological and pathological processes.
Purpose of the Study:
- To review the multifaceted roles of the SphK/S1P axis in diverse viral infections.
- To examine how SphK/S1P influences viral replication and host-pathogen interactions.
- To assess potential therapeutic strategies targeting S1P signaling in viral diseases.
Main Methods:
- Literature review of studies on SphK/S1P axis and viral infections.
- Analysis of research on sphingolipid metabolism in the context of virus replication.
- Examination of signaling pathways regulated by S1P during viral pathogenesis.
Main Results:
- The SphK/S1P axis is critical for regulating cellular activities in infections by respiratory, enterovirus, hepatitis, herpes, and arboviruses.
- SphK isoforms (SphK1, SphK2) levels are manipulated by viruses.
- The axis exhibits context-dependent pro- or anti-viral activities, influenced by the host immune system and intracellular signaling.
Conclusions:
- The SphK/S1P axis plays significant roles in viral replication and pathogenesis.
- Understanding S1P signaling provides insights into viral infection mechanisms.
- Targeting S1P metabolism and signaling presents potential therapeutic avenues for viral infections.
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