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Updated: Aug 15, 2025
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
Published on: September 8, 2023
Novel micro-MRI approach for subchondral trabecular bone analysis in patients with hip osteoarthritis is comparable
Tea Duvančić, Siniša Škokić, Igor Erjavec
1Domagoj Delimar, Department of Orthopedic Surgery, University Hospital Center Zagreb, Šalata 6, 10000 Zagreb, Croatia, domagoj.delimar@gmail.com.
Aim:
To test the agreement between a newly developed micro-magnetic resonance imaging (MRI) analysis of the subchondral bone and the micro-computed tomography (CT) approach.
Methods:
Samples obtained from 10 patients with osteoarthritis undergoing total hip arthroplasty were scanned with a 7.0 T micro-MRI. Proton density-weighted images and proton density-weighted images with fat suppression were obtained. The results were validated with a micro-CT device. Micro-MRI and micro-CT scans of the same sample were aligned, and regions of interest were delineated on equal areas of the sample. Bone volume fraction was calculated by using in-house plugins. The agreement between the methods was tested with Bland-Altman analysis.
Results:
The agreement between the methods was good, with average difference of 2.167%. The differences between the methods were not significant (P=0.272, t test).
Conclusion:
The novel micro-MRI approach could be used for subchondral bone analysis. With further optimization for clinical MRI machines, the approach can be also used in the diagnostics of hip osteoarthritis.
