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[Angina Pectoris and the Importance of Coronary Microcirculation in Practice]

Julia Stehli1, Alessandro Candreva1, Barbara E Stähli1

  • 1Klinik für Kardiologie, Universitätsspital Zürich, Schweiz.

Praxis
|January 4, 2023
PubMed

Insights

Microvascular angina, common in post-menopausal women, is often undetected due to underused diagnostic tools. Early detection and targeted therapy improve outcomes for coronary microvascular dysfunction.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Internal Medicine

Context:

  • Microvascular angina is a frequent manifestation of coronary microvascular dysfunction (CMD).
  • It disproportionately affects post-menopausal women over 50, impacting quality of life and prognosis.
  • CMD is often undiagnosed due to limited use of diagnostic tools for coronary microvascular function assessment.

Purpose:

  • To highlight the clinical significance of microvascular angina and coronary microcirculation.
  • To emphasize the diagnostic challenges and consequences of underdetection.
  • To outline current and future therapeutic strategies for CMD.

Summary:

  • Invasive coronary catheterization, including coronary flow reserve and acetylcholine provocation testing, can diagnose CMD.
  • Targeted therapies involve lifestyle changes, secondary prevention, and anti-anginal medications.
  • Current research aims to develop novel diagnostic and therapeutic approaches for improved CMD management.

Impact:

  • Improved detection and management of microvascular angina can enhance patient quality of life and clinical outcomes.
  • Increased utilization of diagnostic tools for coronary microvascular function is crucial.
  • Advancements in research promise better therapeutic strategies for coronary microvascular disease.

Keywords:
CoronaropathieCoronary artery diseaseIschämie bei nicht-obstruktiven KoronararterienKoronare HerzkrankheitMikrozirkulationsstörungcoronary microvascular dysfunctiondysfonctionnement microvasculaire coronaireischemia with non-obstructive coronary arteriesischémie avec artères coronaires non obstructives

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