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Updated: Aug 15, 2025
![Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F68356.jpg&w=3840&q=50)
Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
Published on: April 25, 2025
Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy
Ryotaro Onoue1, Hiroyuki Watanabe1, Masahiro Ono1
1Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. hwatanabe@pharm.kyoto-u.ac.jp.
Abstract:
Targeted radionuclide therapy using Auger electrons is a promising strategy in cancer treatment. A DNA-binding Hoechst-tagged radioiodinated BODIPY derivative ([125I]BH) has been prepared as an Auger therapeutic agent. [125I]BH showed high accumulation in the nucleus of HeLa cells and cytotoxicity caused by DNA double-strand breaks.
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