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Related Experiment Videos

Cholecystokinin secretion in pregnancy.

G Rådberg1, J F Rehfeld, P Cantor

  • 1Dept. of Surgery I, Sahlgren's Hospital, Gothenburg, Sweden.

Scandinavian Journal of Gastroenterology
|August 1, 1987
PubMed
Summary

Pregnancy increases gallbladder volume and impairs contraction, raising gallstone risk. However, gallbladder behavior in pregnancy is not due to impaired cholecystokinin (CCK) secretion, despite altered CCK response.

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Area of Science:

  • Gastroenterology
  • Reproductive Medicine
  • Endocrinology

Background:

  • Gallbladder volume increases during pregnancy, leading to impaired contraction and a higher risk of gallstones.
  • Cholesterol crystal retention in the gallbladder lumen is a consequence of impaired gallbladder function during pregnancy.
  • Cholecystokinin (CCK) is a key hormone regulating food-induced gallbladder contraction.

Purpose of the Study:

  • To investigate plasma cholecystokinin (CCK) concentrations in pregnant and non-pregnant women.
  • To determine the relationship between CCK secretion and gallbladder contraction during pregnancy.
  • To clarify the role of CCK in the altered gallbladder function observed in pregnancy.

Main Methods:

  • Plasma CCK concentrations were measured in fasting and stimulated states in pregnant women and controls.

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  • Gallbladder volume was assessed using ultrasound in a subset of participants.
  • CCK response was stimulated using an oral preparation known to induce gallbladder contraction.

    • Main Results:

    • Basal CCK plasma concentrations were comparable between pregnant women and controls.
    • The gallbladder's response to CCK stimulation was significantly increased in pregnancy.
    • CCK secretion demonstrated a strong correlation with gallbladder emptying efficiency.

    Conclusions:

    • The altered gallbladder behavior during pregnancy is not attributable to impaired CCK secretion.
    • Pregnancy influences gallbladder function and CCK response, but not basal CCK levels.
    • The findings suggest a complex interplay between pregnancy hormones and the CCK pathway in regulating gallbladder motility.