Related Experiment Video
Updated: Aug 15, 2025
12:07
Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays
Published on: March 14, 2011
26.1K
Natural killer cells for antiviral therapy
Davey M Smith1, Jolie R Schafer2, Brian Tullius3
1Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Science Translational Medicine
|January 4, 2023
Summary
Natural killer (NK) cell immunotherapy shows promise for viral infections. This review covers NK cell responses, clinical trials, and platforms for developing NK cell therapies against viruses.
Area of Science:
- Immunology
- Infectious Diseases
- Cell Therapy
Background:
- Natural killer (NK) cells are crucial innate immune cells with cytotoxic and cytokine-producing functions.
- NK cell activity is vital for controlling viral infections and eliminating infected cells.
- Dysregulation of NK cell responses can contribute to viral pathogenesis.
Purpose of the Study:
- To review the role of NK cells in response to various viral infections.
- To discuss current clinical applications of NK cell-based immunotherapy for viral diseases.
- To explore platforms for generating NK cell products for therapeutic use.
Main Methods:
- Literature review of studies on NK cell responses to viruses.
- Analysis of ongoing clinical trials involving NK cell immunotherapy for viral infections.
- Examination of technologies and platforms for NK cell product development.
Main Results:
- Evidence demonstrates diverse NK cell responses to different viral pathogens.
- Several clinical trials are evaluating the safety and efficacy of NK cell therapies in viral infections.
- Various platforms, including genetic engineering and co-culture systems, are being developed to enhance NK cell therapeutic potential.
Conclusions:
- NK cell immunotherapy represents a promising strategy for managing viral infections.
- Further research and development of NK cell platforms are needed to optimize therapeutic outcomes.
- NK cell-based approaches hold potential for novel treatments against challenging viral diseases.
Related Concept Videos
01:29Immune Response Against Viral Pathogens
874
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
874
01:27Cytotoxic T Cells-mediated Immune Response
1.1K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.1K
01:28Cells of the Innate Immune Response
1.9K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.9K
01:25Immune Surveillance by NK Cells and Phagocytes
1.6K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.6K
01:40Cell-mediated Immune Responses
69.6K
Overview
69.6K
01:27Tumor Immunotherapy
622
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
622