Related Experiment Video
Updated: Aug 15, 2025

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
Published on: November 11, 2022
Perioperative Management and Considerations for Patients With Voltage-Gated Sodium Channel Mutations: A Pediatric
John F Fahy1, Eric W Emerling, Lynne M Sterni
1From the Department of Anesthesiology, Naval Medical Center San Diego, San Diego, California.
Abstract:
A 13-year-old girl with a voltage-gated sodium channel mutation (SCN8A)-associated intractable epilepsy presented for bilateral mastectomy for painful juvenile fibroadenomatosis. Sodium channel mutations are more frequently diagnosed with continued advances in genetic testing. Understanding the effects of sodium channel mutations is important to provide safe anesthetic care to these patients. In this article, we discuss what is known regarding the physiology of SCN8A channels and the anesthetic considerations when caring for patients with an SCN8A mutation.
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