Related Experiment Video
Updated: Aug 15, 2025
07:30
HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
Published on: July 9, 2016
7.4K
[Psychedelics in Psychiatry - Development and Current State in Germany]
Uwe Herwig1,2,3, Lea Mertens4, Sergio Pérez Rosal5,6
1Zentrum für Psychiatrie Reichenau, Akademisches Lehrkrankenhaus Universität Konstanz, Reichenau, Germany.
Fortschritte Der Neurologie-Psychiatrie
|January 4, 2023
Summary
Psychedelic research is advancing, showing therapeutic potential for psychiatric conditions. Challenges remain in clinical integration and safety, but future applications in Germany are possible.
Area of Science:
- Psychopharmacology
- Neuroscience
- Psychiatry
Context:
- Clinical research on psychedelic substances is experiencing a resurgence.
- Evidence supports efficacy in various psychiatric conditions, with legal approval in some regions.
- Germany is considering the future clinical application of psychedelics.
Purpose:
- To review the historical background of psychedelic use in therapy.
- To explore psycho-phenomenology, mechanisms of action, and safety of psychedelics.
- To discuss the current research landscape and professional organization in Germany.
Summary:
- This manuscript examines the therapeutic potential of psychedelics, covering their history, effects, and indications.
- It addresses challenges in establishing a clinical framework for psychedelic-assisted therapy.
- The current status of research and professional societies in Germany are presented in a global context.
Impact:
- Highlights the growing scientific evidence for psychedelic therapeutics.
- Identifies critical unresolved issues for clinical implementation.
- Provides context for the future of psychedelic medicine in Germany and internationally.
Related Concept Videos
01:22CNS Stimulants: Psychedelic Agents
213
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
213
01:27Hallucinogens and Psychedelics
246
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
246
01:06Altered States of Awareness
328
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
328
01:29Psychodynamic Therapy
116
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
116
01:30Psychosurgery
94
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
94
01:28Drug Therapy
83
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
83