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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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ANCA-associated refractory vasculitis with multiple systemic involvement: A rare case report.

Fadi Kharouf1, John Moshe Gomori2, Chamutal Gur1

  • 1Department of Medicine, Rheumatology Unit, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

International Journal of Rheumatic Diseases
|January 4, 2023
PubMed
Summary
This summary is machine-generated.

A 65-year-old woman with hearing loss was diagnosed with ANCA-associated vasculitis. Rituximab treatment showed significant clinical and radiological improvement, highlighting its efficacy in managing this rare condition.

Keywords:
anti-neutrophil cytoplasmic antibody-associated vasculitisaortitiscranial neuropathymagnetic resonance imagingrituximab

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Area of Science:

  • Neurology
  • Rheumatology
  • Otolaryngology

Background:

  • ANCA-associated vasculitis (AAV) is a rare autoimmune disease.
  • AAV can affect multiple organ systems, including the nervous system and blood vessels.

Observation:

  • A 65-year-old female presented with bilateral hearing loss, otalgia, and hyperacusis.
  • MRI revealed a skull base inflammatory process encasing the internal carotid artery.
  • Diagnosis was confirmed by elevated inflammatory markers and positive perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA).

Findings:

  • The patient developed peripheral nerve palsy, aortitis, hepatitis, peripheral neuropathy, and uveitis.
  • Initial treatments with corticosteroids, azathioprine, and cyclophosphamide were ineffective.
  • Rituximab therapy resulted in significant clinical and radiological improvement.

Implications:

  • This case underscores the diverse clinical manifestations of AAV.
  • It highlights the diagnostic challenges posed by skull base involvement in AAV.
  • Rituximab demonstrates significant therapeutic potential for refractory AAV with multi-system involvement.