Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

33.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
33.5K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

65
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
65
Yeast Signaling01:28

Yeast Signaling

14.7K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
14.7K
Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

45
Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
45
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

57
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
57

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initiation of Hybrid Polyketide-Nonribosomal Peptide Biosynthesis via Two Distinct Pathways in <i>C. elegans</i>.

ACS chemical biology·2026
Same author

A Semester-Long Laboratory in Molecular Biology and Biochemistry Focusing on the Discovery of Novel β-Lactamase Inhibitors From Streptomyces.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology·2026
Same author

A multifunctional polyketide synthase in nematodes produces divergent families of signaling molecules that control different developmental arrests.

bioRxiv : the preprint server for biology·2026
Same author

Maternal age modulates progeny social behavior via a small RNA-neuropeptide axis.

bioRxiv : the preprint server for biology·2026
Same author

Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders.

Molecular cell·2026
Same author

A Cold Stress-Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same journal

Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer.

Nature·2026
Same journal

Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies.

Nature·2026
Same journal

Vaccination elicits HIV broadly neutralizing antibodies in primates.

Nature·2026
Same journal

Child online safety needs more than social-media bans.

Nature·2026
Same journal

Ebola preparedness must start with ecosystems and before humans show symptoms.

Nature·2026
Same journal

AI tools can speed up thinking, but evidence still comes from the lab bench.

Nature·2026
See all related articles

Related Experiment Video

Updated: Aug 15, 2025

Author Spotlight: Examining Volatile Sex Pheromone Influence on Male C. elegans Behavior
06:49

Author Spotlight: Examining Volatile Sex Pheromone Influence on Male C. elegans Behavior

Published on: August 9, 2024

2.5K

Pathogenic bacteria modulate pheromone response to promote mating.

Taihong Wu1,2, Minghai Ge1,2, Min Wu1,2

  • 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

Nature
|January 4, 2023
PubMed
Summary
This summary is machine-generated.

Pathogens can change animal social behaviors. In C. elegans worms, a bacterial pathogen alters mating behavior by changing how worms sense pheromones, promoting reproduction and adaptation.

More Related Videos

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
09:35

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation

Published on: July 17, 2018

9.0K
Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

14.7K

Related Experiment Videos

Last Updated: Aug 15, 2025

Author Spotlight: Examining Volatile Sex Pheromone Influence on Male C. elegans Behavior
06:49

Author Spotlight: Examining Volatile Sex Pheromone Influence on Male C. elegans Behavior

Published on: August 9, 2024

2.5K
The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
09:35

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation

Published on: July 17, 2018

9.0K
Microscopy of Fission Yeast Sexual Lifecycle
07:47

Microscopy of Fission Yeast Sexual Lifecycle

Published on: March 9, 2016

14.7K

Area of Science:

  • Neuroscience
  • Behavioral Ecology
  • Microbiology

Background:

  • Host-pathogen interactions significantly influence animal social behaviors.
  • Neuronal mechanisms driving pathogen-induced social behavior changes remain largely unknown.

Purpose of the Study:

  • To investigate the neuronal basis of pathogen-induced social behavior plasticity in Caenorhabditis elegans.
  • To understand how bacterial pathogens modulate social interactions and mating behavior.

Main Methods:

  • Exposure of adult C. elegans hermaphrodites to Pseudomonas aeruginosa.
  • Analysis of chemoreceptor STR-44 expression in AWA sensory neurons.
  • Assessment of pheromone response and mating behavior following pathogen exposure.

Main Results:

  • Pathogen exposure induced STR-44 expression in AWA neurons, altering pheromone avoidance.
  • STR-44 in AWA neurons is essential for pathogen-induced changes in pheromone response.
  • C. elegans hermaphrodites increased mating rates with males after pathogen exposure, dependent on STR-44.

Conclusions:

  • Pathogen-induced plasticity in social behavior is mediated by the chemoreceptor STR-44 in C. elegans.
  • This mechanism promotes genetic diversity and host adaptation by increasing mating rates.
  • The study reveals a direct link between pathogen presence and altered social behavior via specific neuronal pathways.