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Ageing at Molecular Level: Role of MicroRNAs

Sanjay Yadav1, Sana Sarkar2, Anuj Pandey2

  • 1Department of Biochemistry, All India Institute of Medical Sciences, Raebareli, UP, India. syaiims@hotmail.com.

Sub-Cellular Biochemistry
|January 4, 2023
PubMed

Insights

Aging triggers numerous diseases, but the molecular links remain unclear. MicroRNAs (miRNAs) show promise in understanding the complex relationship between aging and disease development.

Area of Science:

  • Gerontology and Molecular Biology
  • Focuses on the molecular mechanisms underlying the aging process and its association with various diseases.

Background:

  • Aging is a significant risk factor for major diseases like cancer and cardiovascular disorders.
  • Despite extensive research, the molecular pathways connecting aging to disease pathogenesis are not fully understood.
  • Cellular hallmarks of aging, including senescence and telomere dysfunction, are implicated in age-related diseases.

Purpose of the Study:

  • To explore the role of microRNAs (miRNAs) in the aging process across different tissues and organs.
  • To investigate the molecular mechanisms through which miRNAs influence age-related diseases.
  • To enhance the understanding of the interplay between aging and associated pathologies.

Main Methods:

  • Literature review and synthesis of existing research on miRNAs, aging, and disease.
  • Analysis of molecular pathways involving miRNAs in cellular aging processes.
  • Comparative study of miRNA expression patterns in aging tissues and age-related diseases.

Main Results:

  • MicroRNAs play a crucial role in regulating cellular processes fundamental to aging.
  • Dysregulation of specific miRNAs is linked to common aging hallmarks and various age-related diseases.
  • miRNA-based mechanisms offer potential therapeutic targets for mitigating aging and disease progression.

Conclusions:

  • MicroRNAs are key regulators connecting the aging process with the development of age-related diseases.
  • Targeting miRNAs presents a promising strategy for understanding and potentially intervening in aging and associated pathologies.
  • Further research into miRNA function is essential for advancing gerontology and disease prevention.
Keywords:
Age-related diseaseAgeingBiomarkersSenescencemiRNAs

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