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Related Experiment Video

Updated: Aug 15, 2025

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

CircRNA and Ageing.

Ebrahim Mahmoudi^1,2, Murray J Cairns^3,4

¹School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.

Sub-Cellular Biochemistry

|January 4, 2023

Summary

This summary is machine-generated.

Circular RNAs (circRNAs) are key regulators of aging and related diseases. These unique RNA molecules show promise as biomarkers and therapeutic targets for promoting longevity and treating age-associated conditions.

Keywords:

Ageing Gene regulation Transcription Translation ceRNA networks circRNA miRNA

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Last Updated: Aug 15, 2025

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

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Published on: September 29, 2011

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Area of Science:

Molecular Biology
Genetics
Gerontology

Background:

Circular RNAs (circRNAs) are formed via back splicing and perform diverse molecular functions.
circRNAs are dynamically regulated during development and accumulate with age.
They play roles in aging pathways and age-related diseases like cancer and neurological disorders.

Purpose of the Study:

To review recent advances in understanding circRNA changes during aging.
To explore the role of circRNAs in age-related diseases.
To discuss the potential of circRNAs as biomarkers and therapeutic targets for aging.

Main Methods:

Literature review of recent studies on circRNAs and aging.
Analysis of circRNA functions in cellular pathways related to senescence.
Examination of circRNA implications in age-associated pathologies.

Main Results:

circRNAs are dynamically regulated and accumulate during the aging process.
circRNAs are implicated in cellular senescence and various age-related diseases.
circRNAs exhibit potential as diagnostic/prognostic biomarkers and therapeutic targets for aging.

Conclusions:

circRNAs are crucial molecular determinants of aging and associated diseases.
circRNAs offer potential for novel interventions to modulate aging and longevity.
Further research into circRNAs can advance the diagnosis and treatment of pathological aging.