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Clinical characteristics of 14 pediatric mycoplasma pneumoniae pneumonia associated thrombosis: a retrospective study

Y Fu1, T Q Zhang1, C J Dong1

  • 1Department of Respiratory Medicine, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin, China.

BMC Cardiovascular Disorders
|January 4, 2023
PubMed
Abstract

Insights

Mycoplasma pneumoniae pneumonia (MPP)-associated thrombosis can affect any blood vessel, presenting with varied symptoms. Early diagnosis and prompt anticoagulant therapy lead to a favorable prognosis for most pediatric patients.

Area of Science:

  • Pediatric Thrombosis
  • Infectious Disease Complications
  • Respiratory Medicine

Background:

  • Mycoplasma pneumoniae pneumonia (MPP) is a common childhood infection.
  • MPP can lead to serious extrapulmonary complications, including thrombosis.
  • Understanding MPP-associated thrombosis is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate the clinical characteristics of pediatric patients with MPP-associated thrombosis.
  • To evaluate the long-term prognosis of MPP-associated thrombosis.
  • To improve the diagnostic and therapeutic strategies for this condition.

Main Methods:

  • Retrospective review of medical records of 14 children diagnosed with MPP-associated thrombosis.
  • Data collected from January 2016 to April 2020 at Tianjin Children's Hospital.
  • Analysis of clinical presentation, thrombotic events, D-dimer levels, and treatment outcomes.

Main Results:

  • Ages ranged from 3 to 12 years; various thrombotic events observed, including pulmonary embolism, cerebral infarction, and cardiac embolism.
  • All patients presented with elevated D-dimer levels.
  • Three cases with cerebral embolism experienced neurological sequelae; others had favorable outcomes after thrombolysis and anticoagulation.

Conclusions:

  • MPP-associated thrombosis can manifest in diverse vascular beds with non-specific symptoms.
  • Elevated D-dimer in refractory MPP warrants suspicion for thrombosis.
  • Timely anticoagulant therapy is associated with a good long-term prognosis in pediatric MPP-associated thrombosis.
Keywords:
ChildrenMycoplasma pneumoniaeThrombosis

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