Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

218
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
218

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

X-linked Emery-Dreifuss muscular dystrophy: a multicenter, Italian, cohort study.

Journal of neurology·2026
Same author

Analysis of the Italian cohort of late-onset Pompe disease (LOPD) patients after 10 and 15 years of therapy with alglucosidase alfa.

Journal of neurology·2025
Same author

Investigating electrospun shape memory patches as Gentamicin drug delivery system.

International journal of pharmaceutics·2025
Same author

CTNND1-Related Disorder: New Insight on Prenatal Phenotype.

American journal of medical genetics. Part A·2024
Same author

Effect of different diet composition on the fat profile of two different black soldier fly larvae populations.

Animal : an international journal of animal bioscience·2024
Same author

Delivering hydrosoluble compounds through the skin: what are the chances?

International journal of pharmaceutics·2023
Same journal

Preparation and Characterisation of Pre-Nanoemulsions Encapsulating Multiple Oil-Soluble Active Substances.

Drug development and industrial pharmacy·2026
Same journal

Synergistic anticancer potential of andrographolide and paclitaxel: a dose-reduction strategy to minimize toxicity and enhance therapeutic efficacy.

Drug development and industrial pharmacy·2026
Same journal

Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy.

Drug development and industrial pharmacy·2026
Same journal

Biocompatible and bio-orthogonal surface engineering of inorganic self-assembled nanocrystals for precision drug targeting: a review.

Drug development and industrial pharmacy·2026
Same journal

Next-generation drug delivery for age-related macular degeneration: promise of controlled release formulations.

Drug development and industrial pharmacy·2026
Same journal

Design, optimization, and evaluation of ferulic acid-loaded cubosomal cream for enhanced topical delivery and anti-hyperpigmentation efficacy.

Drug development and industrial pharmacy·2026
See all related articles

Related Experiment Video

Updated: Aug 15, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.4K

Cellulose Acetate Trimellitate Microspheres Containing NSAIDS.

P Giunchedi1, M Ltorre1, L Maggi1

  • 1Dipartimento di Chimica Farmaceutica, Università di Pavia, via Taramelli 12, 27100, Pavia, Italy.

Drug Development and Industrial Pharmacy
|January 5, 2023
PubMed
Summary
This summary is machine-generated.

This study developed drug-loaded microspheres using cellulose acetate trimellitate and spray drying. The enteric polymer formulation successfully delayed the release of indomethacin and ketoprofen, demonstrating controlled drug delivery potential.

More Related Videos

Bacterial Cellulose Spheres that Encapsulate Solid Materials
04:42

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

4.5K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.0K

Related Experiment Videos

Last Updated: Aug 15, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.4K
Bacterial Cellulose Spheres that Encapsulate Solid Materials
04:42

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

4.5K
Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
08:39

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

9.0K

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) like indomethacin and ketoprofen are widely used.
  • Developing effective drug delivery systems is crucial for optimizing NSAID therapy and minimizing side effects.

Purpose of the Study:

  • To encapsulate indomethacin and ketoprofen into microspheres using cellulose acetate trimellitate.
  • To characterize the physicochemical properties and in vitro drug release of the developed microspheres.
  • To evaluate the potential of enteric polymer-based microspheres for controlled drug delivery.

Main Methods:

  • Spray drying technique was employed to encapsulate NSAIDs with cellulose acetate trimellitate.
  • Preparation of organic solutions with varying polymer-drug weight ratios.
  • Characterization of microparticles for yield, shape, size, morphology, and drug content.
  • In vitro drug release studies were conducted using a pH change method with a flow-through cell apparatus.

Main Results:

  • Drug-loaded microspheres were successfully produced via spray drying.
  • Characterization confirmed the formation of microparticles with specific morphological features.
  • In vitro release studies demonstrated a typical delayed drug release profile.
  • The pH-dependent solubility of the enteric polymer governed the drug release kinetics.

Conclusions:

  • Cellulose acetate trimellitate is a suitable enteric polymer for developing NSAID-loaded microspheres.
  • Spray drying is an effective method for producing these controlled-release drug delivery systems.
  • The developed microspheres show potential for targeted and sustained release of indomethacin and ketoprofen.