Cellulose Acetate Trimellitate Microspheres Containing NSAIDS.

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Non-steroidal anti-inflammatory drugs (NSAIDs) like indomethacin and ketoprofen are widely used.
• Developing effective drug delivery systems is crucial for optimizing NSAID therapy and minimizing side effects.

Purpose of the Study:

• To encapsulate indomethacin and ketoprofen into microspheres using cellulose acetate trimellitate.
• To characterize the physicochemical properties and in vitro drug release of the developed microspheres.
• To evaluate the potential of enteric polymer-based microspheres for controlled drug delivery.

Main Methods:

• Spray drying technique was employed to encapsulate NSAIDs with cellulose acetate trimellitate.
• Preparation of organic solutions with varying polymer-drug weight ratios.
• Characterization of microparticles for yield, shape, size, morphology, and drug content.
• In vitro drug release studies were conducted using a pH change method with a flow-through cell apparatus.

Main Results:

• Drug-loaded microspheres were successfully produced via spray drying.
• Characterization confirmed the formation of microparticles with specific morphological features.
• In vitro release studies demonstrated a typical delayed drug release profile.
• The pH-dependent solubility of the enteric polymer governed the drug release kinetics.

Conclusions:

• Cellulose acetate trimellitate is a suitable enteric polymer for developing NSAID-loaded microspheres.
• Spray drying is an effective method for producing these controlled-release drug delivery systems.
• The developed microspheres show potential for targeted and sustained release of indomethacin and ketoprofen.