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Neurovirulence effects of dengue-2 viruses on the rhesus (Macaca mulatta) brain and spinal cord
S Angsubhakorn1, J B Moe, N J Marchette
1Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Abstract:
Vaccines prepared from attenuated virus can cause symptomatic viral infection of the central nervous system. In the present study, dengue-2 parental and its live attenuated viruses were tested by intrathalamic and intraspinal injections in rhesus monkeys. The dengue-2 viruses were found to be only very weakly neurovirulent when injected directly into the brain or spinal cord of rhesus monkeys.