Related Experiment Video
Updated: Aug 15, 2025
10:52
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
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IgG4-related hypophysitis: A monocentric experience from North India
Ananda Mohan Chakraborty1, Sushant Kumar Sahoo2, Debajyoti Chatterjee3
1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Surgical Neurology International
|January 5, 2023
Summary
Immunoglobulin G4-related hypophysitis (IgG4-RH) is a rare condition. Early diagnosis requires a high index of suspicion, and 18F-FDG PET scans aid in identifying hypophysitis and other organ involvement.
Area of Science:
- Endocrinology
- Pathology
- Radiology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition.
- IgG4-related hypophysitis (IgG4-RH) is a rare cause of hypophysitis, potentially misdiagnosed as idiopathic.
- Hypophysitis prevalence in operative specimens is low (0.2-0.88%).
Purpose of the Study:
- To analyze the clinical characteristics, diagnosis, and treatment outcomes of IgG4-RH.
- To highlight the role of imaging in diagnosing IgG4-RH.
Main Methods:
- Retrospective registry-based cohort study.
- Analysis of medical records and clinical data of biopsy-proven and suspected IgG4-RH patients.
- Exploration of treatment outcomes.
Main Results:
- Four cases of IgG4-RH identified among 2006 sellar lesions.
- Headaches were the most common symptom; cortisol deficiency was the most frequent pituitary dysfunction.
- 18F-FDG PET was useful for diagnosis; surgery was the primary treatment.
Conclusions:
- IgG4-RH is a rare entity requiring a high index of suspicion for accurate diagnosis.
- 18F-FDG PET is valuable for diagnosing hypophysitis and extrapituitary lesions.
- Further research is needed to optimize treatment strategies.
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