Meteorin-Like Protein Levels Decrease in Patients With Acute Ischaemic Stroke.

Area of Science:

• Biochemistry
• Neurology
• Medical Diagnostics

Background:

• Acute ischemic stroke (AIS) diagnosis and management rely on identifying reliable blood-based biomarkers.
• Ongoing research explores novel biomarkers for improved patient outcomes in AIS.

Purpose of the Study:

• To investigate meteorin-like protein (Metrnl) levels in adipose tissue of patients diagnosed with AIS.
• To assess the potential of Metrnl as a diagnostic marker for AIS.

Main Methods:

• Comparative analysis of Metrnl, total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in 35 AIS patients and 30 healthy controls.
• Enzyme-linked immunosorbent assays (ELISA) were used to measure Metrnl levels.
• Magnetic resonance imaging (MRI) confirmed AIS diagnosis.

Main Results:

• AIS patients exhibited significantly lower Metrnl and TAC levels compared to healthy controls (p=0.001 and p=0.009, respectively).
• AIS patients showed significantly higher TOS and OSI levels (p<0.001 for both).
• A Metrnl cut-off value of ≤1.63% demonstrated 91.43% sensitivity and 71.43% specificity for AIS detection. A negative correlation was observed between Metrnl levels and infarct diameter.

Conclusions:

• Metrnl levels decrease in AIS patients, inversely correlating with infarct diameter.
• Elevated oxidative stress (increased TOS and OSI) and reduced antioxidant capacity (decreased TAC) are characteristic of AIS.
• Metrnl shows promise as a biomarker for assessing AIS severity and potentially aiding diagnosis.