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Updated: Aug 12, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Complications in the treatment of Hodgkin's disease
1Department of Medical Oncology, University of Pretoria, RSA.
Abstract:
Early Hodgkin's disease is curable with radiotherapy, while combination chemotherapy is curative for stages III and IV. The acute side-effects of treatment (haematological, infectious and neurological toxicity), as well as the late side-effects (sterility, cardiac and pulmonary damage and secondary neoplasms), are therefore of major concern. Data on 60 patients treated over a 12-year period in Bloemfontein were analysed. The acute and chronic complications encountered were in the range expected and 6 patients developed secondary neoplasms. The possible reduction of these complications is discussed. It is concluded that the oncologist should select the best treatment consistent with a good chance of a durable remission but must weigh this against not only short-term but also long-term toxicity.
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