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Updated: Aug 15, 2025

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COVID-19 in patients with pulmonary alveolar proteinosis: a European multicentre study

Spyros A Papiris1, Ilaria Campo2, Francesca Mariani2

  • 1General University Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.

ERJ Open Research
|January 5, 2023
PubMed

Insights

Adult patients with Pulmonary Arterial Hypertension (PAP) have similar COVID-19 infection rates to the general population but face higher risks of hospitalization and death. Preventive measures are crucial, and the impact of iGM-CSF should be evaluated.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Pulmonary Arterial Hypertension (PAP) is a severe cardiopulmonary condition.
  • COVID-19 poses significant risks to vulnerable populations.
  • Understanding infection outcomes in PAP patients is critical.

Purpose of the Study:

  • To assess COVID-19 infection rates in adult PAP patients.
  • To evaluate the severity of COVID-19 outcomes (hospitalization, death) in this cohort.
  • To highlight the need for targeted preventive strategies.

Main Methods:

  • Retrospective analysis of adult PAP patients diagnosed with COVID-19.
  • Comparison of infection rates with the general population.
  • Analysis of hospitalization and mortality data.

Main Results:

  • Adult PAP patients exhibited similar COVID-19 infection rates compared to the general population.
  • However, PAP patients experienced significantly higher rates of hospitalization and death following COVID-19 infection.
  • The role of iGM-CSF in outcomes requires further investigation.

Conclusions:

  • Adult PAP patients are a vulnerable group requiring specific attention during the COVID-19 pandemic.
  • Preventive strategies against COVID-19 are essential for this population.
  • Further research into factors like iGM-CSF is needed to optimize care.

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