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Updated: Aug 15, 2025

Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
Published on: October 15, 2016
Exploiting multivalency and cooperativity of gold nanoparticles for binding phosphatidylinositol
Flavio Della Sala1,2, Elisa Ceresara1, Fabrizio Micheli3
1University of Padova, Department of Chemical Sciences, via Marzolo, 1 35131 Padova, Italy. leonard.prins@unipd.it.
Abstract:
Cationic, monolayer-protected gold nanoparticles provide a multivalent charged surface and a hydrophobic monolayer that synergistically contribute to the binding of phosphatidylinositol (3,4,5)-trisphosphate, a relevant biomarker. The observed dissociation constant is in the picomolar region, providing the possibility of using these gold nanoparticles for the selective extraction of this molecule from biological fluids.

