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DKK1 is a strong candidate for mesiodens and taurodontism

Piranit Kantaputra1,2, Peeranat Jatooratthawichot3, Naomi Kottege4

  • 1Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Clinical Genetics
|January 5, 2023
PubMed

Abstract:

A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.

Keywords:
WNT signalingmesiodenssupernumerary toothtaurodontism

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