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Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
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DKK1 is a strong candidate for mesiodens and taurodontism
Piranit Kantaputra1,2, Peeranat Jatooratthawichot3, Naomi Kottege4
1Center of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
Clinical Genetics
|January 5, 2023
Abstract:
A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.
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