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Alkyl amines and ethers as traceless hydride donors in [1,5]-hydride transfer cascade reactions
Yao-Bin Shen1, Fangzhi Hu2, Shuai-Shuai Li2
1College of Chemistry, Chemical Engineering and Materials Science, Zaozhuang University, Zaozhuang 277160, China.
Abstract:
The use of alkyl amines and ethers as traceless hydride donors in [1,5]-hydride transfer cascade reactions represents a promising strategy that greatly enriches redox-neutral hydride transfer chemistry. This review summarizes the remarkable progress made in this field, and focuses on (1) alkyl amines as traceless hydride donors in cascade [1,5]-hydride transfer/elimination reactions and (2) alkyl ethers as traceless hydride donors in [1,5]-hydride transfer cascade reactions. The reaction mechanisms, features, scope, limitations, and synthetic applications are included, where appropriate. Importantly, its powerful ability in allene synthesis and the combination with [Re]-vinylidene and carbocation chemistries render this strategy attractive enough to inspire chemists to develop colorful reactions for building molecular complexity.
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