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Formulation and Characterization of Bioactive Agent Containing Nanodisks
Published on: March 17, 2023
Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application
Xiaoming Zhong1, Jianqiong Yang2, Hongyan Liu3
1Department of Oncology Radiotherapy, Jiangxi Cancer Hospital, Nanchang, China.
Abstract:
Amphotericin B (AmB) is regarded as a first-line therapy against life-threatening invasive fungal infections. Due to its poor oral bioavailability, AmB is restricted to intravenous administration in clinical practice. As science continues to move forward, two lipid-based formulations are successfully developed for oral AmB administration, currently undergoing phase I clinical trials. Encouragingly, lipid-AmB conjugates with emulsions also exhibit a better bioavailability, which may be another strategy to design oral AmB formulation in clinical practice. Thus, this review mainly focused on the two lipid-based formulations in clinical trials, and discussed the potential perspectives of AmB-lipid conjugation-loaded nanocochleates and emulsions.
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