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Updated: Aug 15, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Access to functionalized alkynylcyclopropanes via reductive radical-polar crossover-based reactions of 1,3-enynes
Beibei Zhang1, Junfei Luo1, Yewen Fang2,3
1Institute of Mass Spectrometry, School of Materials Science and Chemical Engineering, Ningbo University, No. 818 Fenghua Road, Ningbo 315211, China. luojunfei@nbu.edu.cn.
Abstract:
Herein, using a single-electron-transfer reduction-based radical-polar crossover process as a strategy, protocols dealing with the preparation of functionalized alkynylcyclopropanes have been successfully developed via the reactions of 1,3-enynes with alkyl radicals. In addition to redox-neutral photocatalysis, nickel catalysis with zinc as the reductant is also an alternative to enable reactions of 1,3-enynes with redox-active N-hydroxyphthalimide esters. The synthetic application of alkynylcyclopropane has also been demonstrated.
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