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Theranostics for COVID-19 Antiviral Drugs: Prospects and Challenges for Worldwide Precision/Personalized Medicine

Caíque Manóchio1, Sabrina Torres-Loureiro1, Mariana M Scudeler1

  • 1Departamento de Patologia, Genética e Evolução, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil.

Omics : a Journal of Integrative Biology
|January 5, 2023
PubMed

Insights

Theranostics, combining therapeutics and diagnostics, is crucial for optimizing antiviral treatments for COVID-19. This approach enhances drug efficacy and safety, aiding clinical trials for new antiviral drug candidates.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Medical Diagnostics

Background:

  • Coronavirus disease 2019 (COVID-19) presents as a complex systemic illness with variable patient outcomes.
  • The advent of antiviral drugs necessitates advanced strategies for effective COVID-19 management.
  • Current treatment protocols require optimization for both efficacy and safety.

Purpose of the Study:

  • To highlight the critical role of theranostics in improving COVID-19 treatment outcomes.
  • To emphasize the value of theranostics in optimizing antiviral drug efficacy and safety.
  • To demonstrate how theranostics can facilitate the design and execution of clinical trials for antiviral drug candidates.

Main Methods:

  • Expert review of theranostics principles and applications in infectious diseases.
  • Analysis of theranostic potential for existing COVID-19 antiviral drugs, including remdesivir, Paxlovid™, and molnupiravir.
  • Discussion of theranostics' contribution to future antiviral drug development and clinical research.

Main Results:

  • Theranostic approaches offer a pathway to personalize and enhance antiviral therapy for COVID-19.
  • Integration of diagnostics with therapeutics can significantly improve the safety and effectiveness profiles of antiviral medications.
  • Theranostics provides a framework for more efficient and informative clinical trials of novel antiviral agents.

Conclusions:

  • Theranostics is essential for efficient and safe health interventions against COVID-19.
  • The fusion of therapeutics and diagnostics is vital for managing current and future viral pandemics.
  • Adoption of theranostics principles will be key to addressing 21st-century health crises.
Keywords:
COVID-19antiviralsbiomarkerspandemicpersonalized medicinetheranostics

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