Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

1.0K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.0K
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

21
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
21
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

1.1K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
1.1K
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers01:24

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

814
Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
814

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal pace timing for left bundle branch area pacing with or without an additional LV lead: results from the CSPOT study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Intravascular Lithotripsy to Facilitate Extraction of Very Old Cardiac Implantable Electronic Devices Leads.

Journal of cardiovascular electrophysiology·2026
Same author

Ultra-Low Cryoablation for Scar-Related VT Ablation: Results From the US Early Feasibility Study.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Unbiased Characterization of Atrial Fibrillation Phenotypic Architecture Provides Insight Into Genetic Liability and Clinically Relevant Outcomes.

Circulation. Genomic and precision medicine·2026
Same author

Role of concomitant endomyocardial biopsy in non-ischemic cardiomyopathy with ventricular arrhythmias.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2026
Same author

Timing and incidence of symptomatic early recurrence following pulmonary vein isolation with pulsed-field compared with radiofrequency ablation.

Heart rhythm·2026

Related Experiment Video

Updated: Aug 15, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.3K

Substrate Mapping Alters Ventricular Tachycardia Inducibility.

Asad A Aboud1, Giovanni Davogustto2, Oluwaseun Adeola3

  • 1Ascension Saint Thomas Heart Center, Nashville, TN (A.A.A.).

Circulation. Arrhythmia and Electrophysiology
|January 5, 2023
PubMed
Summary
This summary is machine-generated.

Substrate mapping during ventricular tachycardia (VT) ablation can alter VT inducibility. This mechanical effect impacts procedure planning and outcome assessment, potentially explaining recurrent VT.

Keywords:
atrioventricular nodecatheterelectrodesinfarctionlaboratories

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

842
Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

14.8K

Related Experiment Videos

Last Updated: Aug 15, 2025

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

1.3K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

842
Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

14.8K

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Programmed electrical stimulation (PES) is crucial for initiating ventricular tachycardia (VT) to guide mapping and assess ablation success.
  • The study investigates whether substrate mapping, a common electrophysiological technique, influences VT inducibility through mechanical manipulation of critical cardiac sites.

Purpose of the Study:

  • To test the hypothesis that substrate mapping alters VT inducibility by mechanically affecting critical sites.
  • To evaluate the impact of substrate mapping on the success of VT ablation procedures.

Main Methods:

  • Twenty-eight patients with scar-related left ventricular VT underwent repeated PES.
  • Group I (n=14) had PES after substrate mapping; Group II (n=14) had PES after a period of sedation/anesthesia without mapping.
  • VT inducibility was categorized as same VT (type I), different VT (type II), or no VT (type III) after the second PES.

Main Results:

  • Group I showed significantly lower VT inducibility (21% same VT, 64% different VT, 14% no VT) compared to Group II (71% same VT, 21% different VT, 7% no VT) after the second PES (P=0.017).
  • Patients in Group I also had a shorter initial VT cycle length and required more extrastimuli for induction in the first PES.
  • No significant differences were observed in patient demographics or baseline characteristics between the groups.

Conclusions:

  • The mechanical aspects of substrate mapping frequently change VT inducibility.
  • These findings have significant implications for planning catheter ablation procedures and evaluating their immediate outcomes.
  • Altered VT inducibility may also explain some cases of recurrent VT that are not identified during the initial procedure.