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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
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A case study on genomic imprinting facilitates student learning.

Lara K Goudsouzian1, Stanley M Lo2

  • 1Department of Biology, DeSales University, Center Valley, Pennsylvania.

Advances in Physiology Education
|January 5, 2023
PubMed
Summary

This study shows that using a case study improved student understanding of genomic imprinting, a complex genetics topic. Students found this problem-based learning approach effective and enjoyable.

Keywords:
active learningcase studyepigeneticsgenomic imprinting

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Area of Science:

  • Molecular Biology
  • Genetics Education

Background:

  • Genomic imprinting is an abstract concept in genetics that often challenges students.
  • Problem-based learning, particularly through case studies, can enhance understanding of complex topics.

Purpose of the Study:

  • To evaluate the effectiveness of an interrupted case study for teaching genomic imprinting.
  • To assess student learning gains and attitudes toward the case study method.

Main Methods:

  • An interrupted case study using popular news articles was developed for an intermediate molecular biology course.
  • Student learning was assessed via pre/post true/false questions, and attitudes were surveyed.

Main Results:

  • Student performance on assessment questions significantly improved after the case study intervention.
  • Students reported increased knowledge and positive attitudes, finding the case study beneficial and enjoyable.

Conclusions:

  • The developed case study is an effective instructional tool for teaching genomic imprinting.
  • Case studies provide an engaging method for students to learn challenging molecular biology concepts.