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Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
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Making a case for endovascular approaches for neural recording and stimulation
Brianna Thielen1, Huijing Xu1, Tatsuhiro Fujii2
1Alfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States of America.
Journal of Neural Engineering
|January 5, 2023
Summary
Minimally invasive endovascular electrodes offer a safer alternative to traditional brain implants. This review compares their efficacy for neural recording and stimulation against direct-contact methods.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Medical Devices
Background:
- Direct-contact electrodes for neural recording and stimulation require invasive surgery.
- Existing electrodes range from non-invasive scalp types to penetrating microelectrodes.
- Open brain surgery poses significant risks to patients.
Purpose of the Study:
- To review the development and application of endovascular electrodes.
- To compare the efficacy of endovascular electrodes with direct-contact electrodes.
- To present potential clinical applications and advantages of endovascular approaches.
Main Methods:
- Review of existing research on endovascular electrode development and application.
- Comparative analysis of endovascular and direct-contact electrode capabilities.
- Discussion of clinical applications and benefits of minimally invasive techniques.
Main Results:
- Endovascular electrodes can be delivered via catheterization, reducing surgical risk.
- Comparison demonstrates the relative efficacy of different endovascular electrode types.
- Potential clinical applications highlight the advantages over direct-contact methods.
Conclusions:
- Endovascular electrodes represent a promising, less invasive alternative for neural interfacing.
- Minimally invasive endovascular approaches mitigate risks associated with traditional brain surgery.
- Further research and development can expand the clinical utility of these devices.

