Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spontaneous platelet aggregation: observations on potential mechanisms.

J Mehta1, P Mehta, D Lawson

  • 1University of Florida College of Medicine, Department of Medicine, Gainesville.

Thrombosis Research
|February 1, 1987
PubMed
Summary

We found that secondary platelet aggregation (SPA) is linked to thromboxane A2 (TXA2) release. Blocking the TXA2 receptor fully stopped SPA, indicating a potential therapeutic target.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laboratory based experiments to assess the use of green and food based compost to improve water quality in a Sustainable Drainage (SUDS) device such as a swale.

The Science of the total environment·2012
Same author

A randomised, phase II study of intetumumab, an anti-αv-integrin mAb, alone and with dacarbazine in stage IV melanoma.

British journal of cancer·2011
Same author

Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences.

Science (New York, N.Y.)·2010
Same author

Some Changes which take place in the Lungs and Pleura, chiefly in Pulmonary Tuberculosis, as shown by Skiagraphy.

Medico-chirurgical transactions·2010
Same author

A Study of some Points in Relation to the Administration of Tuberculin T.R: Controlled by Observation of the Opsonic Index in Pulmonary Tuberculosis.

Medico-chirurgical transactions·2010
Same author

Symposium: the handicapped child [abridged].

Proceedings of the Royal Society of Medicine·2010

Area of Science:

  • Cardiovascular Research
  • Hematology
  • Pharmacology

Background:

  • Secondary platelet aggregation (SPA) is a critical process in hemostasis and thrombosis.
  • The precise mechanisms and mediators of SPA, particularly in apparently healthy individuals, require further elucidation.
  • Understanding SPA's triggers is crucial for developing targeted antithrombotic therapies.

Observation:

  • SPA was identified in three young, healthy women.
  • SPA was associated with thromboxane A2 (TXA2) release.
  • Partial inhibition was observed with ADP-inhibitor apyrase and alpha 2-adrenoceptor blocker yohimbine.

Findings:

  • In vitro aspirin or TXA2 synthetase inhibitor OKY-046 did not abolish SPA, despite inhibiting TXA2 generation.
  • Oral aspirin and in vitro TXA2-endoperoxide receptor blocker SQ 29,548 significantly inhibited SPA.

Related Experiment Videos

  • TXA2-endoperoxide receptor blockade completely abolished the secondary wave of aggregation.

    • Implications:

    • These findings suggest SPA is primarily mediated by TXA2 acting on its receptor.
    • TXA2-endoperoxide receptor blockers demonstrate significant potential for managing SPA.
    • Such agents may offer therapeutic benefits for patients with SPA and ischemic conditions.