Related Experiment Video
Updated: Aug 15, 2025
Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally
Published on: April 25, 2025
Preclinical murine models to study lung infection with Mycobacterium abscessus complex
Francesca Nicola1, Daniela M Cirillo1, Nicola I Lorè1
1Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Preclinical mouse models are crucial for developing new treatments for Mycobacterium abscessus lung infections. These models help test novel antimicrobials and immune-modulating therapies against antibiotic-resistant NTM pulmonary disease.
Area of Science:
- Infectious Diseases
- Microbiology
- Pulmonary Medicine
Background:
- Mycobacterium abscessus causes difficult-to-treat non-tuberculous mycobacterial (NTM) pulmonary disease.
- Limited therapeutic options exist due to antibiotic resistance mechanisms.
- Urgent need for new antimicrobials and immunomodulatory drugs.
Conclusions:
- A comprehensive overview of available murine models for M. abscessus lung infection is provided.
- These models are vital for characterizing acute/chronic infections and assessing novel therapeutic outcomes.
- The review supports the development of effective strategies against M. abscessus infections.
More Related Videos
10:38Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
Published on: September 9, 2015
06:43Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
Published on: January 13, 2016