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Updated: Aug 15, 2025
09:17
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
21.7K
Fluid dynamics in aging-related dementias.
Thierno M Bah1, Dominic A Siler2, Aseel H Ibrahim3
1Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
Neurobiology of Disease
|January 5, 2023
Summary
The brain
Area of Science:
- Neuroscience
- Immunology
- Aging Research
Background:
- Recent studies reveal novel pathways for CNS fluid movement, immune cell trafficking, and waste clearance.
- These pathways, including the glymphatic system and meningeal lymphatics, are potentially impaired in aging and dementia.
- Alzheimer's disease (AD) and related dementias may involve dysfunction of these clearance systems.
Purpose of the Study:
- To provide an overview of the glymphatic and meningeal lymphatic systems.
- To review methods for studying glymphatic flow in humans and animals.
- To discuss the role of these systems in CNS homeostasis and disease.
Main Methods:
- Review of experimental studies in human and animal models.
- Discussion of current techniques for assessing glymphatic flow.
- Analysis of existing evidence and controversies regarding CNS fluid dynamics.
Main Results:
- Novel pathways for CNS fluid and waste transport have been identified.
- Evidence suggests these pathways may be compromised in aging and neurodegenerative diseases like AD.
- Current understanding of glymphatic system function in health and disease is evolving.
Conclusions:
- The glymphatic and meningeal lymphatic systems play crucial roles in CNS health.
- Impairment of these systems is implicated in aging and dementia, including Alzheimer's disease.
- Non-invasive imaging is needed to fully elucidate these pathways across the lifespan.
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