Janus-Inspired Core-Shell Structure Hydrogel Programmatically Releases Melatonin for Reconstruction of Postoperative...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Oncology

Background:

• Surgery for bone tumors often leads to recurrence and significant bone defects.
• Current treatments lack effective strategies for simultaneous tumor eradication and bone regeneration.

Purpose of the Study:

• To develop a Janus-inspired core-shell bone scaffold for programmed, differential release of melatonin.
• To inhibit residual tumor cells post-resection and promote bone repair.
• To investigate the scaffold's efficacy in vitro and in vivo.

Main Methods:

• Fabrication of a Janus-inspired core-shell hydrogel scaffold.
• Characterization using scanning electron microscopy.
• In vitro and in vivo drug release and degradation studies.
• In vitro and in vivo biological evaluations for anti-tumor and osteogenic effects.

Main Results:

• Scanning electron microscopy confirmed the core-shell structure.
• Drug release and degradation studies demonstrated programmed differential melatonin release.
• In vitro and in vivo experiments showed significant inhibition of tumor growth.
• Positive effects on osteogenesis were confirmed in vivo and in vitro.

Conclusions:

• The Janus-inspired core-shell scaffold effectively delivers melatonin for dual action: inhibiting bone tumor recurrence and promoting bone repair.
• This scaffold offers a novel approach for differential and programmed drug delivery in bone tissue engineering and oncology.