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Inadvertent stem cell transfer demonstrating a way for tolerance induction.
1Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria; Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.
Kidney International
|January 5, 2023
Summary
Hematopoietic chimerism enabled tolerance after kidney transplant in a pediatric patient with immune deficiency. This study reveals hematopoietic stem cells within human kidneys, offering new insights into transplantation tolerance.
Area of Science:
- Immunology
- Transplantation Science
- Pediatric Medicine
Background:
- Combined immune deficiencies pose challenges for solid organ transplantation.
- Tolerance induction is crucial for long-term graft survival.
- Hematopoietic chimerism is an emerging strategy for inducing transplant tolerance.
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