Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Day-3 embryo cell number on pregnancy, obstetric and perinatal outcomes in frozen-thawed single blastocyst transfer cycles.

Frontiers in endocrinology·2026
Same author

Corrigendum to "In vitro assessment of the effect of Porphyra haitanensis polysaccharides on the intestinal flora of allergic mice" [Int. J. Biol. Macromol. 311 (2025) 143950].

International journal of biological macromolecules·2026
Same author

Exploring key genes related to ferroptosis amino acid metabolism in lung adenocarcinoma based on transcriptome data.

Discover oncology·2026
Same author

Correlation between pathogens of chronic suppurative otitis media and nasopharyngeal colonization in the Taklamakan Desert region.

Scientific reports·2026
Same author

Exogenous salicylic acid alleviates high temperature-induced inhibition of flower bud differentiation in red raspberry by modulating anther development and phytohormone homeostasis.

BMC plant biology·2026
Same author

Integrated transcriptomic and metabolomic analyses reveal melatonin-mediated drought response in red raspberry at the squaring stage.

BMC plant biology·2026

Related Experiment Video

Updated: Aug 15, 2025

Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

50.1K

How does carrageenan cause colitis? A review.

Juanjuan Guo1, Xuke Shang1, Peilin Chen2

  • 1College of Oceanology and Food Sciences, Quanzhou Normal University, Quanzhou, Fujian 362000, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.

Carbohydrate Polymers
|January 5, 2023
PubMed
Summary

Carrageenan, a food additive, may cause intestinal inflammation by altering gut bacteria or directly activating inflammatory pathways. Further research is needed for safe food industry use and colitis treatment.

Keywords:
CarrageenanIntestinal inflammationIntestinal microbiotaMucus barrierPathogenesis

More Related Videos

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
12:37

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS

Published on: September 11, 2012

47.1K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

47.7K

Related Experiment Videos

Last Updated: Aug 15, 2025

Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

50.1K
Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
12:37

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS

Published on: September 11, 2012

47.1K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

47.7K

Area of Science:

  • Gastroenterology
  • Immunology
  • Food Science

Background:

  • Carrageenan is a widely used food additive with controversial safety regarding intestinal inflammation.
  • Existing evidence suggests carrageenan may induce or worsen colitis, but its precise inflammatory mechanisms remain unclear.

Purpose of the Study:

  • To review the pathogenesis of carrageenan-induced colitis.
  • To analyze inflammatory bowel disease mechanisms and carrageenan's role.
  • To summarize evidence from cellular and animal models on carrageenan's colitis-inducing pathways.

Main Methods:

  • Literature review and analysis of existing studies on carrageenan and colitis.
  • Examination of cellular and animal models investigating carrageenan's effects on the gut.
  • Discussion of inflammatory bowel disease pathogenesis in relation to carrageenan.

Main Results:

  • Two primary pathways for carrageenan-induced colitis were identified.
  • Pathway 1: Alteration of intestinal microbiota, specifically reducing Akkermansia muciniphila, leading to mucosal barrier destruction and immune response.
  • Pathway 2: Direct interaction of carrageenan with epithelial cell receptors, activating the NF-κB inflammatory pathway.

Conclusions:

  • Carrageenan's inflammatory mechanisms involve both microbiota disruption and direct epithelial cell activation.
  • Understanding these pathways can guide the development of colitis treatments.
  • This review provides insights for safe processing and utilization of carrageenan in the food industry.