Related Experiment Video

Updated: Aug 15, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

21.3K

ATR Inhibition in Advanced Urothelial Carcinoma

Ryan C Leibrandt1, Mei-Juan Tu2, Ai-Ming Yu2

  • 1University of California at Davis School of Medicine, Department of Internal Medicine, Division of Hematology Oncology, Sacramento, California, United States of America.

Clinical Genitourinary Cancer
|January 5, 2023
PubMed

Insights

Ataxia telangiectasia and Rad3-related (ATR) inhibitors show promise for treating advanced urothelial carcinoma. By targeting ATR, these drugs may induce DNA damage, halting cancer cell replication and division.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The ataxia telangiectasia and Rad3-related (ATR) and checkpoint kinase 1 (CHK1) pathway is crucial for maintaining genomic integrity.
  • ATR plays a vital role in suppressing replication stress and repairing DNA damage.
  • ATR inhibition is a potential therapeutic strategy in oncology, particularly for cancers with unmet treatment needs.

Purpose of the Study:

  • To review preclinical and clinical data on ATR inhibitors in advanced urothelial carcinoma.
  • To evaluate the efficacy of ATR inhibitors as monotherapy and in combination with chemotherapy.
  • To assess the potential of ATR inhibitors as novel therapies for advanced urothelial carcinoma.

Main Methods:

  • Review of contemporary preclinical and clinical studies.
  • Analysis of data from 4 ATR inhibitors.
  • Evaluation of monotherapy and combination treatment regimens.

Main Results:

  • ATR inhibitors demonstrate potential in preclinical and clinical settings for advanced urothelial carcinoma.
  • Combination therapy with chemotherapy may enhance the efficacy of ATR inhibitors.
  • Further investigation is warranted to establish the role of ATR inhibitors in treatment paradigms.

Conclusions:

  • ATR inhibition represents a promising therapeutic avenue for advanced urothelial carcinoma.
  • The combination of ATR inhibitors with chemotherapy warrants further clinical evaluation.
  • Targeting the ATR pathway offers a novel strategy to improve outcomes in urothelial cancer.

More Related Videos

In Vivo Luminal Measurement of Distension-Evoked Urothelial ATP Release in Rodents09:17

In Vivo Luminal Measurement of Distension-Evoked Urothelial ATP Release in Rodents

Published on: September 7, 2022

1.7K
Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction06:01

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction

Published on: October 6, 2022

1.6K

Related Concept Videos

Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
28
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K