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Silver-Nanoparticle-Embedded Short Amphiphilic Peptide Nanostructures and Their Plausible Application to Reduce
Satyendra Kumar Tripathi1, Khushboo Kesharwani1, Deepanshi Saxena2
1Department of Chemistry, School of Chemical Science and Technology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, MP, 470003, India.
Chemmedchem
|January 5, 2023
Summary
Alzheimer's disease progression is linked to gut microbiota imbalance. Novel nanostructures show potential for treating gut-related neurodegeneration by modulating the gut-brain axis.
Area of Science:
- Microbiology
- Neuroscience
- Nanotechnology
Background:
- The microbiota-gut-brain axis (GBA) is crucial in neurodegenerative disease development.
- Gut dysbiosis and associated neuroinflammation are observed in Alzheimer's disease (AD).
- AD pathogenesis may originate in the gut, necessitating gut microbiota modulation.
Purpose of the Study:
- To explore therapeutic strategies targeting gut microbiota imbalance in neurodegenerative diseases.
- To investigate the potential of novel nanostructures for microbiota-related conditions.
Main Methods:
- Synthesis of antibacterial silver-nanoparticle-peptide amphiphile (AgNPs-sPA) nanostructures.
- Evaluation of nanostructure biocompatibility and cytotoxicity.
- Assessment of nanostructures as drug delivery agents for bacterial infections.
Main Results:
- The synthesized AgNPs-sPA nanostructures exhibited high biocompatibility.
- The nanostructures demonstrated low cytotoxicity.
- These findings support their use as model drug delivery agents.
Conclusions:
- Gut microbiota imbalance is implicated in neurodegenerative diseases like AD.
- AgNPs-sPA nanostructures show promise as therapeutic agents.
- These nanostructures may offer a novel approach for microbiota-triggered neurodegeneration treatment.
