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Related Concept Videos

Teeth01:15

Teeth

558
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
558
Tooth Anatomy01:21

Tooth Anatomy

829
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
829

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Tooth number abnormality: from bench to bedside.

Han Zhang1, Xuyan Gong1, Xiaoqiao Xu1

  • 1Department of Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.

International Journal of Oral Science
|January 5, 2023
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Summary
This summary is machine-generated.

Tooth number abnormalities, including agenesis and supernumerary teeth, arise from disrupted signaling pathways during development. This review covers mechanisms, clinical findings, and potential treatments for these common dental anomalies.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Dental Medicine

Background:

  • Tooth number abnormalities, such as tooth agenesis and supernumerary teeth, are prevalent congenital dental disorders.
  • These anomalies result from disruptions in the complex signaling pathways governing tooth development, including Wnt, BMP, FGF, Shh, and Eda.
  • The precise molecular mechanisms underlying these developmental disruptions remain incompletely understood.

Purpose of the Study:

  • To review the fundamental processes of tooth development.
  • To summarize recent advancements in understanding the mechanisms of tooth number abnormalities.
  • To discuss current clinical investigations and potential therapeutic strategies informed by developmental biology.

Main Methods:

  • Literature review of developmental biology, genetics, and clinical studies.
  • Synthesis of information on key signaling pathways involved in tooth morphogenesis.
  • Analysis of recent clinical case reports and treatment outcomes.

Main Results:

  • Detailed overview of epithelial-mesenchymal interactions crucial for tooth formation.
  • Identification of critical signaling pathways (Wnt, BMP, FGF, Shh, Eda) and their roles in tooth number regulation.
  • Compilation of recent clinical findings and emerging treatment modalities for dental anomalies.

Conclusions:

  • Understanding developmental signaling is key to addressing tooth number abnormalities.
  • This review bridges basic science research with clinical applications for diagnosis and treatment.
  • Further research into developmental mechanisms can guide innovative therapeutic interventions for dental anomalies.