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Blood pressure in heart failure management and prevention

Daichi Maeda1, Taishi Dotare1, Yuya Matsue2

  • 1Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|January 5, 2023
PubMed

Insights

Hypertension significantly impacts heart failure development and prognosis. Effective blood pressure management, considering heart failure treatments, is crucial for cardiovascular health and patient outcomes.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Heart Failure Pathophysiology

Background:

  • Hypertension is a primary driver of cardiovascular diseases, including heart failure.
  • The mechanisms linking hypertension to heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) differ.
  • Blood pressure management is critical for preventing heart failure and influencing prognosis in affected patients.

Purpose of the Study:

  • To explore how hypertension contributes to HFrEF and HFpEF.
  • To examine the effect of hypertension on the incidence of heart failure.
  • To review optimal blood pressure management strategies in heart failure patients.

Main Methods:

  • Literature review of studies on hypertension, heart failure, and blood pressure management.
  • Analysis of the relationship between blood pressure and cardiovascular events in patients with and without heart failure.
  • Discussion of the impact of guideline-directed medical therapy (GDMT) for heart failure on blood pressure.

Main Results:

  • The association between systolic blood pressure (SBP) and cardiovascular events is linear in non-heart failure patients but J-shaped or inverse linear in heart failure patients.
  • Heart failure medications influence blood pressure and their efficacy depends on baseline blood pressure.
  • Blood pressure management and pharmacotherapy differ significantly between patients with and without heart failure.

Conclusions:

  • Understanding the distinct roles of hypertension in HFrEF and HFpEF is essential.
  • Rigorous blood pressure control can reduce heart failure incidence.
  • Tailored blood pressure management, considering GDMT, is vital for optimizing outcomes in heart failure patients.

Keywords:
Blood pressureDASH dietHeart failureHypertensionPharmacotherapy

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